Assay Detail
Functional
CHEMBL616623
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Serotonin dimers: application of the bivalent ligand approach to the design of new potent and selective 5-HT(1B/1D) agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 9.12 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144397 | — | — | 1 | 10.05 |
| CHEMBL342323 | — | — | 1 | 10.00 |
| CHEMBL144128 | — | — | 1 | 9.72 |
| CHEMBL147851 | — | — | 1 | 9.66 |
| CHEMBL357830 | — | — | 1 | 9.59 |
| CHEMBL146720 | — | — | 1 | 9.55 |
| CHEMBL356277 | — | — | 1 | 9.52 |
| CHEMBL357478 | — | — | 1 | 9.40 |
| CHEMBL147901 | — | — | 1 | 9.36 |
| CHEMBL424128 | — | — | 1 | 9.22 |
| CHEMBL148022 | — | — | 1 | 9.07 |
| CHEMBL147677 | — | — | 1 | 8.80 |
| CHEMBL148314 | — | — | 1 | 8.68 |
| CHEMBL144030 | — | — | 1 | 8.52 |
| CHEMBL343196 | — | — | 1 | 8.40 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.32 |
| CHEMBL128 | SUMATRIPTAN | 4.0 | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144397 | — | EC50 | = | 0.09 | nM | 10.05 |
| CHEMBL342323 | — | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL144128 | — | EC50 | = | 0.19 | nM | 9.72 |
| CHEMBL147851 | — | EC50 | = | 0.22 | nM | 9.66 |
| CHEMBL357830 | — | EC50 | = | 0.26 | nM | 9.59 |
| CHEMBL146720 | — | EC50 | = | 0.28 | nM | 9.55 |
| CHEMBL356277 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL357478 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL147901 | — | EC50 | = | 0.44 | nM | 9.36 |
| CHEMBL424128 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL148022 | — | EC50 | = | 0.85 | nM | 9.07 |
| CHEMBL147677 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL148314 | — | EC50 | = | 2.07 | nM | 8.68 |
| CHEMBL144030 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL343196 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL39 | SEROTONIN | EC50 | = | 4.82 | nM | 8.32 |
| CHEMBL128 | SUMATRIPTAN | EC50 | = | 77.0 | nM | 7.11 |