Assay Detail
Functional
CHEMBL616624
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Effective concentration determined by measuring inhibition of forskolin-stimulated c-AMP formation at 5-hydroxytryptamine 1B receptor stably transfected in CHO cell lines
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Dimerization of sumatriptan as an efficient way to design a potent, centrally and orally active 5-HT1B agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.15 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL158941 | — | — | 1 | 9.24 |
| CHEMBL1185 | ZOLMITRIPTAN | 4.0 | 1 | 7.80 |
| CHEMBL128 | SUMATRIPTAN | 4.0 | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL158941 | — | EC50 | = | 0.58 | nM | 9.24 |
| CHEMBL1185 | ZOLMITRIPTAN | EC50 | = | 15.7 | nM | 7.80 |
| CHEMBL128 | SUMATRIPTAN | EC50 | = | 38.3 | nM | 7.42 |