Assay Detail
Functional
CHEMBL616626
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptor
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Fluorination of 3-(3-(piperidin-1-yl)propyl)indoles and 3-(3-(piperazin-1-yl)propyl)indoles gives selective human 5-HT1D receptor ligands with improved pharmacokinetic profiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.14 | 7.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL294732 | — | — | 1 | 7.18 |
| CHEMBL294547 | — | — | 1 | 6.92 |
| CHEMBL63167 | — | — | 1 | 6.54 |
| CHEMBL292779 | — | — | 1 | 6.37 |
| CHEMBL63799 | — | — | 1 | 6.36 |
| CHEMBL432332 | — | — | 1 | 6.35 |
| CHEMBL67684 | — | — | 1 | 6.29 |
| CHEMBL63432 | — | — | 1 | 6.09 |
| CHEMBL304857 | — | — | 1 | 5.85 |
| CHEMBL65321 | — | — | 1 | 5.82 |
| CHEMBL64004 | — | — | 1 | 5.77 |
| CHEMBL433108 | — | — | 1 | 5.29 |
| CHEMBL63258 | — | — | 1 | 5.00 |
| CHEMBL416688 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL294732 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL294547 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL63167 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL292779 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL63799 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL432332 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL67684 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL63432 | — | EC50 | = | 810.0 | nM | 6.09 |
| CHEMBL304857 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL65321 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL64004 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL433108 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL63258 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL416688 | — | EC50 | = | 103000.0 | nM | - |