Assay Detail
Binding
CHEMBL616637
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Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.
20
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
3-[2-(Pyrrolidin-1-yl)ethyl]indoles and 3-[3-(piperidin-1-yl)propyl]indoles: agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B subtype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.12 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296161 | — | — | 1 | 8.85 |
| CHEMBL331612 | — | — | 1 | 7.82 |
| CHEMBL128 | SUMATRIPTAN | 4.0 | 1 | 7.80 |
| CHEMBL333341 | — | — | 1 | 7.55 |
| CHEMBL116092 | — | — | 1 | 7.52 |
| CHEMBL117579 | — | — | 1 | 7.48 |
| CHEMBL331970 | — | — | 1 | 7.46 |
| CHEMBL905 | RIZATRIPTAN | 4.0 | 1 | 7.39 |
| CHEMBL420965 | — | — | 1 | 7.33 |
| CHEMBL159819 | — | — | 1 | 7.30 |
| CHEMBL326371 | — | — | 1 | 7.06 |
| CHEMBL118012 | — | — | 1 | 6.94 |
| CHEMBL117046 | — | — | 1 | 6.90 |
| CHEMBL420874 | — | — | 2 | 6.84 |
| CHEMBL304857 | — | — | 1 | 6.84 |
| CHEMBL313714 | — | — | 1 | 6.73 |
| CHEMBL324287 | — | — | 1 | 6.68 |
| CHEMBL330803 | — | — | 1 | 6.25 |
| CHEMBL51 | KETANSERIN | 3.0 | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296161 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL331612 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL128 | SUMATRIPTAN | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL333341 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL116092 | — | IC50 | = | 30.2 | nM | 7.52 |
| CHEMBL117579 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL331970 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL905 | RIZATRIPTAN | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL420965 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL159819 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL326371 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL118012 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL117046 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL420874 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL304857 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL313714 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL324287 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL420874 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL330803 | — | IC50 | = | 568.0 | nM | 6.25 |
| CHEMBL51 | KETANSERIN | IC50 | = | 6500.0 | nM | 5.19 |