Assay Detail
Binding
CHEMBL616639
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
61
Total Activities
61
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
3-[3-(Piperidin-1-yl)propyl]indoles as highly selective h5-HT(1D) receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 61 | 7.14 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL358072 | — | — | 1 | 8.48 |
| CHEMBL147148 | — | — | 1 | 8.21 |
| CHEMBL147940 | — | — | 1 | 8.05 |
| CHEMBL146338 | — | — | 1 | 8.05 |
| CHEMBL146483 | — | — | 1 | 8.03 |
| CHEMBL357634 | — | — | 1 | 8.00 |
| CHEMBL147818 | — | — | 1 | 7.89 |
| CHEMBL343648 | — | — | 1 | 7.85 |
| CHEMBL145982 | — | — | 1 | 7.75 |
| CHEMBL147660 | — | — | 1 | 7.62 |
| CHEMBL357007 | — | — | 1 | 7.62 |
| CHEMBL356808 | — | — | 1 | 7.60 |
| CHEMBL333341 | — | — | 1 | 7.57 |
| CHEMBL143893 | — | — | 1 | 7.55 |
| CHEMBL116092 | — | — | 1 | 7.55 |
| CHEMBL146265 | — | — | 1 | 7.47 |
| CHEMBL331970 | — | — | 1 | 7.46 |
| CHEMBL146024 | — | — | 1 | 7.46 |
| CHEMBL347570 | — | — | 1 | 7.40 |
| CHEMBL148233 | — | — | 1 | 7.39 |
| CHEMBL146335 | — | — | 1 | 7.35 |
| CHEMBL143947 | — | — | 1 | 7.32 |
| CHEMBL146391 | — | — | 1 | 7.24 |
| CHEMBL143952 | — | — | 1 | 7.22 |
| CHEMBL143951 | — | — | 1 | 7.20 |
| CHEMBL343667 | — | — | 1 | 7.18 |
| CHEMBL147546 | — | — | 1 | 7.18 |
| CHEMBL146991 | — | — | 1 | 7.13 |
| CHEMBL145997 | — | — | 1 | 7.12 |
| CHEMBL357408 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL358072 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL147148 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL146338 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL147940 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL146483 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL357634 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL147818 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL343648 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL145982 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL147660 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL357007 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL356808 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL333341 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL116092 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL143893 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL146265 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL331970 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL146024 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL347570 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL148233 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL146335 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL143947 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL146391 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL143952 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL143951 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL343667 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL147546 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL146991 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL145997 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL357408 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL147979 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL145849 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL434315 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL343217 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL434125 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL149488 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL147907 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL117046 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL304857 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL423212 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL146891 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL148325 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL146729 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL147555 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL313714 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL356315 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL146023 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL148085 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2112862 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL341897 | — | IC50 | = | 260.0 | nM | 6.58 |