Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL616640

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type CHO
Confidence 8 — Homologous single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 1B (CHEMBL1898)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

3-[3-(Piperidin-1-yl)propyl]indoles as highly selective h5-HT(1D) receptor agonists.
Russell MG, Matassa VG, Pengilley RR, van Niel MB, Sohal B, Watt AP, Hitzel L, Beer MS, Stanton JA, Broughton HB, Castro JL.
J Med Chem (1999) 42 : 4981 -5001
PubMed 10585208 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 6.92 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL128 SUMATRIPTAN 4.0 1 8.00
CHEMBL342330 1 7.15
CHEMBL148071 1 7.11
CHEMBL146396 1 7.09
CHEMBL148110 1 7.07
CHEMBL148087 1 7.02
CHEMBL148194 1 7.01
CHEMBL147853 1 7.00
CHEMBL118012 1 6.96
CHEMBL342805 1 6.92
CHEMBL146131 1 6.85
CHEMBL146628 1 6.82
CHEMBL146132 1 6.80
CHEMBL146502 1 6.77
CHEMBL423022 1 6.70
CHEMBL145815 1 6.68
CHEMBL143890 1 6.68
CHEMBL423749 1 6.68
CHEMBL146285 1 6.64
CHEMBL146150 1 6.46

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL128 SUMATRIPTAN IC50 = 10.0 nM 8.00
CHEMBL342330 IC50 = 71.0 nM 7.15
CHEMBL148071 IC50 = 78.0 nM 7.11
CHEMBL146396 IC50 = 81.0 nM 7.09
CHEMBL148110 IC50 = 85.0 nM 7.07
CHEMBL148087 IC50 = 95.0 nM 7.02
CHEMBL148194 IC50 = 98.0 nM 7.01
CHEMBL147853 IC50 = 100.0 nM 7.00
CHEMBL118012 IC50 = 110.0 nM 6.96
CHEMBL342805 IC50 = 120.0 nM 6.92
CHEMBL146131 IC50 = 140.0 nM 6.85
CHEMBL146628 IC50 = 150.0 nM 6.82
CHEMBL146132 IC50 = 160.0 nM 6.80
CHEMBL146502 IC50 = 170.0 nM 6.77
CHEMBL423022 IC50 = 200.0 nM 6.70
CHEMBL145815 IC50 = 210.0 nM 6.68
CHEMBL143890 IC50 = 210.0 nM 6.68
CHEMBL423749 IC50 = 210.0 nM 6.68
CHEMBL146285 IC50 = 230.0 nM 6.64
CHEMBL146150 IC50 = 350.0 nM 6.46