Assay Detail
Binding
CHEMBL616641
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and serotonergic activity of 3-[2-(pyrrolidin-1-yl)ethyl]indoles: potent agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 7.21 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296161 | — | — | 1 | 8.89 |
| CHEMBL348304 | — | — | 1 | 8.57 |
| CHEMBL161045 | — | — | 1 | 8.36 |
| CHEMBL128 | SUMATRIPTAN | 4.0 | 1 | 7.96 |
| CHEMBL423599 | — | — | 1 | 7.96 |
| CHEMBL349185 | — | — | 1 | 7.92 |
| CHEMBL159683 | — | — | 1 | 7.82 |
| CHEMBL349041 | — | — | 1 | 7.70 |
| CHEMBL116092 | — | — | 1 | 7.55 |
| CHEMBL117579 | — | — | 1 | 7.50 |
| CHEMBL161735 | — | — | 1 | 7.48 |
| CHEMBL164046 | — | — | 1 | 7.41 |
| CHEMBL159759 | — | — | 1 | 7.39 |
| CHEMBL159819 | — | — | 1 | 7.33 |
| CHEMBL420965 | — | — | 1 | 7.33 |
| CHEMBL349893 | — | — | 1 | 7.32 |
| CHEMBL159483 | — | — | 1 | 7.31 |
| CHEMBL160070 | — | — | 1 | 7.31 |
| CHEMBL159650 | — | — | 1 | 7.23 |
| CHEMBL345657 | — | — | 1 | 7.21 |
| CHEMBL161780 | — | — | 1 | 7.21 |
| CHEMBL350153 | — | — | 1 | 7.16 |
| CHEMBL161410 | — | — | 1 | 7.13 |
| CHEMBL326371 | — | — | 1 | 7.07 |
| CHEMBL348864 | — | — | 1 | 7.06 |
| CHEMBL159493 | — | — | 1 | 7.06 |
| CHEMBL349528 | — | — | 1 | 7.03 |
| CHEMBL159627 | — | — | 1 | 7.03 |
| CHEMBL161066 | — | — | 1 | 6.96 |
| CHEMBL348815 | — | — | 1 | 6.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296161 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL348304 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL161045 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL128 | SUMATRIPTAN | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL423599 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL349185 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL159683 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL349041 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL116092 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL117579 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL161735 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL164046 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL159759 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL159819 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL420965 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL349893 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL159483 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL160070 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL159650 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL345657 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL161780 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL350153 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL161410 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL326371 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL348864 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL159493 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL349528 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL159627 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL161066 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL348815 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL420874 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL351303 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL349390 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL324287 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL161192 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL441296 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL435060 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL424154 | — | IC50 | = | 305.0 | nM | 6.52 |
| CHEMBL162296 | — | IC50 | = | 325.0 | nM | 6.49 |
| CHEMBL159381 | — | IC50 | = | 575.0 | nM | 6.24 |
| CHEMBL330803 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL159733 | — | IC50 | = | 575.0 | nM | 6.24 |