Assay Detail
Functional
CHEMBL616718
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel potent 5-HT(1F) receptor agonists: structure-activity studies of a series of substituted N-[3-(1-methyl-4-piperidinyl)-1H-pyrrolo[3,2-b]pyridin-5-yl]amides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 7.79 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104753 | — | — | 1 | 8.03 |
| CHEMBL105958 | — | — | 1 | 7.96 |
| CHEMBL105091 | — | — | 1 | 7.96 |
| CHEMBL102250 | — | — | 1 | 7.96 |
| CHEMBL105955 | — | — | 1 | 7.89 |
| CHEMBL321080 | — | — | 1 | 7.82 |
| CHEMBL420475 | — | — | 1 | 7.68 |
| CHEMBL105722 | — | — | 1 | 7.60 |
| CHEMBL105261 | — | — | 1 | 7.50 |
| CHEMBL104720 | — | — | 1 | 7.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104753 | — | EC50 | = | 9.4 | nM | 8.03 |
| CHEMBL105958 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL105091 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL102250 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL105955 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL321080 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL420475 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL105722 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL105261 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL104720 | — | EC50 | = | 34.0 | nM | 7.47 |