Assay Detail
Binding
CHEMBL616729
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In vitro binding affinity for human 5-hydroxytryptamine 1F receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Substituted furo[3,2-b]pyridines: novel bioisosteres of 5-HT 1F receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.39 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL101690 | — | — | 1 | 8.80 |
| CHEMBL173949 | — | — | 1 | 8.64 |
| CHEMBL369705 | — | — | 1 | 8.54 |
| CHEMBL177238 | — | — | 1 | 8.52 |
| CHEMBL177258 | — | — | 1 | 8.51 |
| CHEMBL103479 | — | — | 1 | 8.12 |
| CHEMBL178066 | — | — | 1 | 8.09 |
| CHEMBL369391 | — | — | 1 | 7.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL101690 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL173949 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL369705 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL177238 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL177258 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL103479 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL178066 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL369391 | — | Ki | = | 13.5 | nM | 7.87 |