Assay Detail
Binding
CHEMBL616743
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor in guinea pig substantia nigra
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
5-hydroxytryptamine receptor 1D (CHEMBL2304407) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
5-cyano-1-[3-(N-methylpyrrolidin-2R-ylmethyl)indol-5-yl] benzimidazole (CP-161,242): A potent, centrally active 5-HT1D receptor agonist and benzodiazepine partial agonist
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.77 | 10.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75642 | — | — | 1 | 10.38 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.07 |
| CHEMBL80189 | — | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75642 | — | EC50 | = | 0.042 | nM | 10.38 |
| CHEMBL39 | SEROTONIN | EC50 | = | 8.5 | nM | 8.07 |
| CHEMBL80189 | — | EC50 | = | 14.0 | nM | 7.85 |