Assay Detail
Binding
CHEMBL616815
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Compound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1C receptor of pig choroid plexus using [3H]mesulergine as the radioligand
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.89 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274866 | — | — | 1 | 6.82 |
| CHEMBL18785 | RU-24969 | — | 1 | 6.54 |
| CHEMBL304008 | — | — | 1 | 5.19 |
| CHEMBL28178 | — | — | 1 | 5.00 |
| CHEMBL27403 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274866 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL18785 | RU-24969 | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL304008 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL28178 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL27403 | — | IC50 | > | 10000.0 | nM | - |