Assay Detail
Functional
CHEMBL616867
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor beta measured as the reduction of forskolin-stimulated cAMP.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
5-HT1D receptor agonist properties of novel 2-[5-[[(trifluoromethyl)sulfonyl]oxy]indolyl]ethylamines and their use as synthetic intermediates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.45 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL143512 | — | — | 1 | 7.75 |
| CHEMBL143767 | — | — | 1 | 7.55 |
| CHEMBL143510 | — | — | 1 | 7.43 |
| CHEMBL143967 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL143512 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL143767 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL143510 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL143967 | — | Ki | = | 88.0 | nM | 7.06 |