Assay Detail
Binding
CHEMBL616887
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-ketanserin from human cloned 5-hydroxytryptamine 2A receptor expressed in CHO-K1 cells.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Some benzenesulfonamido-substituted valerophenones that are selective antagonists for the 5-HT2C receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 6.30 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 8.80 |
| CHEMBL12314 | MESULERGINE | 2.0 | 1 | 7.70 |
| CHEMBL88402 | RS-102,221 | — | 1 | 6.20 |
| CHEMBL90175 | — | — | 1 | 6.10 |
| CHEMBL88894 | — | — | 1 | 6.10 |
| CHEMBL90565 | — | — | 1 | 6.00 |
| CHEMBL91454 | — | — | 1 | 5.90 |
| CHEMBL88193 | — | — | 1 | 5.70 |
| CHEMBL90467 | — | — | 1 | 5.70 |
| CHEMBL89967 | — | — | 1 | 5.60 |
| CHEMBL88571 | — | — | 1 | 5.50 |
| CHEMBL92809 | — | — | 1 | - |
| CHEMBL328375 | — | — | 1 | - |
| CHEMBL313745 | — | — | 1 | - |
| CHEMBL88809 | — | — | 1 | - |
| CHEMBL90267 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267930 | SPIPERONE | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL12314 | MESULERGINE | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL88402 | RS-102,221 | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL90175 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL88894 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL90565 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL91454 | — | Ki | = | 1258.93 | nM | 5.90 |
| CHEMBL88193 | — | Ki | = | 1995.26 | nM | 5.70 |
| CHEMBL90467 | — | Ki | = | 1995.26 | nM | 5.70 |
| CHEMBL89967 | — | Ki | = | 2511.89 | nM | 5.60 |
| CHEMBL88571 | — | Ki | = | 3162.28 | nM | 5.50 |
| CHEMBL92809 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL328375 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL313745 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL88809 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL90267 | — | Ki | < | 10000.0 | nM | - |