Assay Detail
Binding
CHEMBL616962
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Ability to displace [3H]5-CT (1.5 nM) from HeLa cells of human 5-hydroxytryptamine 1B receptor
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HeLa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-affinity relationship investigations of 5-heteroaryl-substituted analogues of the antipsychotic sertindole. A new class of highly selective alpha(1) adrenoceptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 7.34 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL97184 | — | — | 1 | 8.55 |
| CHEMBL97650 | — | — | 1 | 8.38 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.32 |
| CHEMBL328048 | — | — | 1 | 8.23 |
| CHEMBL98299 | — | — | 1 | 8.19 |
| CHEMBL318735 | — | — | 1 | 7.96 |
| CHEMBL94612 | — | — | 1 | 7.85 |
| CHEMBL330603 | — | — | 1 | 7.70 |
| CHEMBL327662 | — | — | 1 | 7.70 |
| CHEMBL318249 | — | — | 1 | 7.55 |
| CHEMBL97422 | — | — | 1 | 7.51 |
| CHEMBL328187 | — | — | 1 | 7.44 |
| CHEMBL329280 | — | — | 1 | 7.35 |
| CHEMBL319352 | — | — | 1 | 7.32 |
| CHEMBL12713 | SERTINDOLE | 4.0 | 1 | 7.25 |
| CHEMBL328940 | — | — | 1 | 7.17 |
| CHEMBL327527 | — | — | 1 | 7.17 |
| CHEMBL421573 | — | — | 1 | 7.12 |
| CHEMBL97333 | — | — | 1 | 7.00 |
| CHEMBL93923 | — | — | 1 | 6.96 |
| CHEMBL317333 | — | — | 1 | 6.70 |
| CHEMBL330171 | — | — | 1 | 6.68 |
| CHEMBL97242 | — | — | 1 | 6.66 |
| CHEMBL420997 | — | — | 1 | 6.47 |
| CHEMBL95175 | — | — | 1 | 6.44 |
| CHEMBL313424 | — | — | 1 | 6.32 |
| CHEMBL318901 | — | — | 1 | 6.25 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL97184 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL97650 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL39 | SEROTONIN | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL328048 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL98299 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL318735 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL94612 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL330603 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL327662 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL318249 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL97422 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL328187 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL329280 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL319352 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL12713 | SERTINDOLE | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL328940 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL327527 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL421573 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL97333 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL93923 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL317333 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL330171 | — | Ki | = | 208.0 | nM | 6.68 |
| CHEMBL97242 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL420997 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL95175 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL313424 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL318901 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL2 | PRAZOSIN | Ki | > | 7700.0 | nM | - |