Assay Detail
Binding
CHEMBL616979
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In vitro binding affinity was measured on serotonergic 5-hydroxytryptamine 2 receptor by displacement of [3H]- ketanserin
18
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Cyclic benzamides as mixed dopamine D2/serotonin 5-HT2 receptor antagonists: potential atypical antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 8.18 | 9.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL83625 | — | — | 2 | 9.42 |
| CHEMBL83195 | — | — | 1 | 9.08 |
| CHEMBL87294 | — | — | 1 | 8.96 |
| CHEMBL85647 | — | — | 1 | 8.74 |
| CHEMBL86013 | — | — | 1 | 8.72 |
| CHEMBL314370 | — | — | 1 | 8.64 |
| CHEMBL314043 | — | — | 1 | 8.54 |
| CHEMBL315925 | — | — | 1 | 8.38 |
| CHEMBL83454 | — | — | 1 | 8.33 |
| CHEMBL41626 | — | — | 1 | 8.29 |
| CHEMBL290937 | — | — | 1 | 8.12 |
| CHEMBL83510 | — | — | 1 | 8.10 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.55 |
| CHEMBL85137 | — | — | 1 | 7.12 |
| CHEMBL314684 | — | — | 1 | 6.85 |
| CHEMBL3144650 | — | — | 1 | 6.82 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL83625 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL83625 | — | IC50 | = | 0.76 | nM | 9.12 |
| CHEMBL83195 | — | IC50 | = | 0.84 | nM | 9.08 |
| CHEMBL87294 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL85647 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL86013 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL314370 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL314043 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL315925 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL83454 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL41626 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL290937 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL83510 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL85137 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL314684 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3144650 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL54 | HALOPERIDOL | IC50 | = | 360.0 | nM | 6.44 |