Assay Detail
Binding
CHEMBL616996
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1B receptor from cloned gorilla membranes expressed in cultured HEK 293 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Gorilla gorilla |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
5-hydroxytryptamine receptor 1B (CHEMBL2304408) ↗| Type | SINGLE PROTEIN |
| Organism | Gorilla gorilla |
Publication
Isochroman-6-carboxamides as highly selective 5-HT1D agonists: potential new treatment for migraine without cardiovascular side effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.65 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL128 | SUMATRIPTAN | 4.0 | 1 | 8.19 |
| CHEMBL71635 | — | — | 1 | 5.52 |
| CHEMBL71838 | — | — | 1 | 5.24 |
| CHEMBL69385 | — | — | 1 | 5.23 |
| CHEMBL71724 | — | — | 1 | 5.14 |
| CHEMBL71907 | — | — | 1 | 4.58 |
| CHEMBL71798 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL128 | SUMATRIPTAN | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL71635 | — | Ki | = | 3023.0 | nM | 5.52 |
| CHEMBL71838 | — | Ki | = | 5775.0 | nM | 5.24 |
| CHEMBL69385 | — | Ki | = | 5862.0 | nM | 5.23 |
| CHEMBL71724 | — | Ki | = | 7242.0 | nM | 5.14 |
| CHEMBL71907 | — | Ki | = | 26021.0 | nM | 4.58 |
| CHEMBL71798 | — | Ki | = | 150300.0 | nM | - |