Assay Detail
Functional
CHEMBL617005
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at 5-hydroxytryptamine 1B receptor by measuring the inhibition of forskolin-stimulated cAMP formation
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
5-HT1B receptor antagonist properties of novel arylpiperazide derivatives of 1-naphthylpiperazine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 7.57 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129813 | — | — | 1 | 7.60 |
| CHEMBL128699 | — | — | 1 | 7.60 |
| CHEMBL2112660 | — | — | 1 | 7.55 |
| CHEMBL338015 | — | — | 1 | 7.52 |
| CHEMBL277120 | — | — | 1 | - |
| CHEMBL129661 | — | — | 1 | - |
| CHEMBL340786 | — | — | 1 | - |
| CHEMBL2112662 | — | — | 1 | - |
| CHEMBL339308 | — | — | 1 | - |
| CHEMBL2112661 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129813 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL128699 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2112660 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL338015 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL277120 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL129661 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL340786 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL2112662 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL339308 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL2112661 | — | EC50 | > | 1000.0 | nM | - |