Assay Detail
Binding
CHEMBL617012
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Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor of rat frontal cortex homogenate
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Frontal cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Synthesis and serotonin receptor affinities of a series of enantiomers of alpha-methyltryptamines: evidence for the binding conformation of tryptamines at serotonin 5-HT1B receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 5.73 | 6.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2093088 | — | — | 1 | 6.15 |
| CHEMBL1788280 | — | — | 1 | 6.02 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 6.01 |
| CHEMBL1416204 | — | — | 1 | 6.01 |
| CHEMBL8165 | 5-METHOXYTRYPTAMINE | — | 1 | 5.99 |
| CHEMBL1788281 | — | — | 1 | 5.89 |
| CHEMBL1744072 | — | — | 1 | 5.84 |
| CHEMBL1788239 | — | — | 1 | 5.50 |
| CHEMBL1788284 | — | — | 1 | 5.46 |
| CHEMBL1788285 | — | — | 1 | 5.37 |
| CHEMBL2093087 | — | — | 1 | 5.29 |
| CHEMBL1744074 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2093088 | — | Ki | = | 707.95 | nM | 6.15 |
| CHEMBL1788280 | — | Ki | = | 954.99 | nM | 6.02 |
| CHEMBL39 | SEROTONIN | Ki | = | 977.24 | nM | 6.01 |
| CHEMBL1416204 | — | Ki | = | 977.24 | nM | 6.01 |
| CHEMBL8165 | 5-METHOXYTRYPTAMINE | Ki | = | 1023.29 | nM | 5.99 |
| CHEMBL1788281 | — | Ki | = | 1288.25 | nM | 5.89 |
| CHEMBL1744072 | — | Ki | = | 1445.44 | nM | 5.84 |
| CHEMBL1788239 | — | Ki | = | 3162.28 | nM | 5.50 |
| CHEMBL1788284 | — | Ki | = | 3467.37 | nM | 5.46 |
| CHEMBL1788285 | — | Ki | = | 4265.8 | nM | 5.37 |
| CHEMBL2093087 | — | Ki | = | 5128.61 | nM | 5.29 |
| CHEMBL1744074 | — | Ki | = | 6165.95 | nM | 5.21 |