Assay Detail
Binding
CHEMBL617017
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pKi value for 5-hydroxytryptamine 2 receptor binding site
7
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
New antipsychotic agents with serotonin and dopamine antagonist properties based on a pyrrolo[2,1-b][1,3]benzothiazepine structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.53 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122536 | METHIOTHEPINE | — | 1 | 9.40 |
| CHEMBL120512 | — | — | 3 | 8.90 |
| CHEMBL333246 | — | — | 1 | 8.10 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 7.90 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122536 | METHIOTHEPINE | Ki | = | 0.3981 | nM | 9.40 |
| CHEMBL120512 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL120512 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL120512 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL333246 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL715 | OLANZAPINE | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL42 | CLOZAPINE | Ki | = | 12.59 | nM | 7.90 |