Assay Detail
Binding
CHEMBL617033
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Tested in vitro for receptor binding affinity against 5-hydroxytryptamine 2 receptor using radioligand [3H]ketanserin
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.94 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93454 | — | — | 1 | 6.80 |
| CHEMBL93781 | — | — | 1 | 6.67 |
| CHEMBL91806 | — | — | 1 | 5.98 |
| CHEMBL327198 | — | — | 1 | 5.80 |
| CHEMBL418953 | — | — | 1 | 5.79 |
| CHEMBL92886 | — | — | 1 | 5.75 |
| CHEMBL26789 | — | — | 1 | 5.64 |
| CHEMBL91689 | — | — | 1 | 5.51 |
| CHEMBL92887 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93454 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL93781 | — | Ki | = | 214.0 | nM | 6.67 |
| CHEMBL91806 | — | Ki | = | 1040.0 | nM | 5.98 |
| CHEMBL327198 | — | Ki | = | 1580.0 | nM | 5.80 |
| CHEMBL418953 | — | Ki | = | 1620.0 | nM | 5.79 |
| CHEMBL92886 | — | Ki | = | 1760.0 | nM | 5.75 |
| CHEMBL26789 | — | Ki | = | 2280.0 | nM | 5.64 |
| CHEMBL91689 | — | Ki | = | 3120.0 | nM | 5.51 |
| CHEMBL92887 | — | Ki | = | 3290.0 | nM | 5.48 |