Assay Detail
Binding
CHEMBL617035
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Binding affinity towards 5-hydroxytryptamine 2 receptor using [3H]- ketanserin as radioligand
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
N,N-di-n-propylserotonin: binding at serotonin binding sites and a comparison with 8-hydroxy-2-(di-n-propylamino)tetralin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.01 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8165 | 5-METHOXYTRYPTAMINE | — | 1 | 6.52 |
| CHEMBL141706 | — | — | 1 | 6.35 |
| CHEMBL7257 | MEBUFOTENIN | 2.0 | 1 | 6.21 |
| CHEMBL169328 | — | — | 1 | 6.18 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 6.03 |
| CHEMBL11760 | — | — | 1 | 5.52 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8165 | 5-METHOXYTRYPTAMINE | Ki | = | 305.0 | nM | 6.52 |
| CHEMBL141706 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL7257 | MEBUFOTENIN | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL169328 | — | Ki | = | 655.0 | nM | 6.18 |
| CHEMBL39 | SEROTONIN | Ki | = | 930.0 | nM | 6.03 |
| CHEMBL11760 | — | Ki | = | 3050.0 | nM | 5.52 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 5350.0 | nM | 5.27 |