Assay Detail
Binding
CHEMBL617056
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Inhibition of human 5-hydroxytryptamine 2A receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
From hit to lead. Analyzing structure-profile relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.13 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL113956 | — | — | 1 | 6.64 |
| CHEMBL116463 | — | — | 1 | 6.17 |
| CHEMBL326263 | — | — | 1 | 6.15 |
| CHEMBL325258 | — | — | 1 | 6.07 |
| CHEMBL117537 | — | — | 1 | 6.02 |
| CHEMBL115249 | — | — | 1 | 6.01 |
| CHEMBL116735 | — | — | 1 | 5.99 |
| CHEMBL325516 | — | — | 1 | 5.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL113956 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL116463 | — | IC50 | = | 683.0 | nM | 6.17 |
| CHEMBL326263 | — | IC50 | = | 715.0 | nM | 6.15 |
| CHEMBL325258 | — | IC50 | = | 854.0 | nM | 6.07 |
| CHEMBL117537 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL115249 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL116735 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL325516 | — | IC50 | = | 1060.0 | nM | 5.97 |