Assay Detail
Binding
CHEMBL617081
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Binding affinity towards human 5-hydroxytryptamine 2A receptor by the displacement of [3H]ketanserin radioligand from the cloned receptor expressed in CHO cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Thiazoles and thiopyridines: novel series of high affinity h5HT(7) ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.39 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL158973 | — | — | 1 | 7.00 |
| CHEMBL158402 | — | — | 1 | 6.64 |
| CHEMBL158285 | — | — | 1 | 6.57 |
| CHEMBL161765 | — | — | 1 | 6.50 |
| CHEMBL159143 | — | — | 1 | 6.32 |
| CHEMBL345803 | — | — | 1 | 6.19 |
| CHEMBL161846 | — | — | 1 | 6.00 |
| CHEMBL161203 | — | — | 1 | 5.92 |
| CHEMBL350166 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL158973 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL158402 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL158285 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL161765 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL159143 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL345803 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL161846 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL161203 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL350166 | — | Ki | > | 200.0 | nM | - |