Assay Detail
Binding
CHEMBL617083
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Binding affinity towards human serotonin 5-hydroxytryptamine 2A receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Selective optimization of side activities: another way for drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.64 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 9.80 |
| CHEMBL708 | ZIPRASIDONE | 4.0 | 1 | 9.52 |
| CHEMBL12713 | SERTINDOLE | 4.0 | 1 | 9.07 |
| CHEMBL285802 | ZOTEPINE | 2.0 | 1 | 9.04 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 8.72 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.48 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.60 |
| CHEMBL716 | QUETIAPINE | 4.0 | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL708 | ZIPRASIDONE | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL12713 | SERTINDOLE | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL285802 | ZOTEPINE | Ki | = | 0.91 | nM | 9.04 |
| CHEMBL715 | OLANZAPINE | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL42 | CLOZAPINE | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL716 | QUETIAPINE | Ki | = | 120.0 | nM | 6.92 |