Assay Detail
Binding
CHEMBL617142
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Binding affinity towards 5-hydroxytryptamine 2 receptor in calf frontal cortex
44
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Frontal cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
3,4-Dihydro-3-amino-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 1. Synthesis and structure--activity relationship studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 5.23 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296395 | — | — | 1 | 6.22 |
| CHEMBL50188 | — | — | 1 | 6.10 |
| CHEMBL51888 | — | — | 3 | 6.00 |
| CHEMBL52785 | — | — | 1 | 6.00 |
| CHEMBL301060 | — | — | 3 | 6.00 |
| CHEMBL299561 | — | — | 1 | 5.70 |
| CHEMBL50993 | — | — | 1 | 5.70 |
| CHEMBL417550 | — | — | 1 | 5.52 |
| CHEMBL50530 | — | — | 3 | 5.52 |
| CHEMBL298534 | — | — | 1 | 5.52 |
| CHEMBL27763 | — | — | 1 | 5.40 |
| CHEMBL50722 | — | — | 1 | 5.40 |
| CHEMBL48925 | — | — | 1 | 5.40 |
| CHEMBL283606 | — | — | 3 | 5.40 |
| CHEMBL300735 | — | — | 3 | 5.30 |
| CHEMBL52485 | — | — | 1 | 5.22 |
| CHEMBL553833 | — | — | 1 | 5.22 |
| CHEMBL54266 | — | — | 1 | 5.22 |
| CHEMBL8412 | IPSAPIRONE | 2.0 | 1 | 5.12 |
| CHEMBL54089 | — | — | 1 | 5.10 |
| CHEMBL52438 | — | — | 1 | 5.00 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 5.00 |
| CHEMBL284912 | — | — | 1 | 5.00 |
| CHEMBL51561 | — | — | 1 | 5.00 |
| CHEMBL52396 | — | — | 1 | 4.52 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 4.31 |
| CHEMBL285010 | — | — | 1 | 4.22 |
| CHEMBL25984 | — | — | 1 | 4.10 |
| CHEMBL545198 | — | — | 1 | - |
| CHEMBL50841 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296395 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL50188 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL51888 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL52785 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL301060 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL299561 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL50993 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL50530 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL417550 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL301060 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL298534 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL48925 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL50722 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL27763 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL283606 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL300735 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL301060 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL52485 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL553833 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL54266 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL8412 | IPSAPIRONE | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL54089 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL300735 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL50530 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL283606 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL51561 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL52438 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL49 | BUSPIRONE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL50530 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL284912 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL300735 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL51888 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL52396 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL56 | 8-OH-DPAT | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL285010 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL283606 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL25984 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL545198 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL264027 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL27995 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL51888 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL50841 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL51985 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL416747 | — | IC50 | > | 1000000.0 | nM | - |