Assay Detail
Binding
CHEMBL617143
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Binding affinity to 5-hydroxytryptamine 2 receptor using calf frontal cortex, [3H]- ketanserin, and spiperone for NSB
23
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
3-amino-3,4-dihydro-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 2. Synthesis and quantitative structure-activity relationship studies of spiro[pyrrolidine- and piperidine-2,3'(2'H)-benzopyrans]
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 4.99 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11265 | — | — | 3 | 6.05 |
| CHEMBL11592 | — | — | 3 | 6.00 |
| CHEMBL422283 | — | — | 1 | 5.54 |
| CHEMBL135952 | — | — | 1 | 5.22 |
| CHEMBL8412 | IPSAPIRONE | 2.0 | 1 | 5.12 |
| CHEMBL334498 | — | — | 1 | 5.08 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 5.00 |
| CHEMBL137486 | — | — | 1 | 4.68 |
| CHEMBL137478 | — | — | 1 | 4.38 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 4.31 |
| CHEMBL283606 | — | — | 1 | 4.22 |
| CHEMBL133375 | — | — | 1 | 4.17 |
| CHEMBL137643 | — | — | 1 | 4.15 |
| CHEMBL137642 | — | — | 1 | - |
| CHEMBL422453 | — | — | 1 | - |
| CHEMBL135335 | — | — | 1 | - |
| CHEMBL135489 | — | — | 1 | - |
| CHEMBL132970 | — | — | 1 | - |
| CHEMBL135490 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11265 | — | IC50 | = | 886.0 | nM | 6.05 |
| CHEMBL11592 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL422283 | — | IC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL11592 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL11592 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL135952 | — | IC50 | = | 5950.0 | nM | 5.22 |
| CHEMBL11265 | — | IC50 | = | 6610.0 | nM | 5.18 |
| CHEMBL8412 | IPSAPIRONE | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL334498 | — | IC50 | = | 8390.0 | nM | 5.08 |
| CHEMBL49 | BUSPIRONE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL11265 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL137486 | — | IC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL137478 | — | IC50 | = | 41400.0 | nM | 4.38 |
| CHEMBL56 | 8-OH-DPAT | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL283606 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL133375 | — | IC50 | = | 67300.0 | nM | 4.17 |
| CHEMBL137643 | — | IC50 | = | 71400.0 | nM | 4.15 |
| CHEMBL135489 | — | IC50 | = | 364000.0 | nM | - |
| CHEMBL135335 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL132970 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL422453 | — | IC50 | = | 112000.0 | nM | - |
| CHEMBL135490 | — | IC50 | = | 233000.0 | nM | - |
| CHEMBL137642 | — | IC50 | = | 793000.0 | nM | - |