Assay Detail
Binding
CHEMBL617169
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In vitro binding affinity against rat 5-hydroxytryptamine 2 receptor.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
New pyridobenzodiazepine derivatives as potential antipsychotics: synthesis and neurochemical study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 7.27 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL304902 | CLOTHIAPINE | 2.0 | 1 | 9.22 |
| CHEMBL415300 | ISOCLOZAPINE | — | 1 | 8.74 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 8.48 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.42 |
| CHEMBL63756 | FLUPERLAPINE | 2.0 | 1 | 8.42 |
| CHEMBL67284 | ISOCLOTHIAPINE | — | 1 | 8.39 |
| CHEMBL63576 | — | — | 1 | 8.21 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.63 |
| CHEMBL67298 | — | — | 1 | 7.54 |
| CHEMBL304493 | — | — | 1 | 7.32 |
| CHEMBL63329 | — | — | 1 | 7.03 |
| CHEMBL63590 | — | — | 1 | 6.99 |
| CHEMBL67355 | — | — | 1 | 6.99 |
| CHEMBL303173 | — | — | 1 | 6.91 |
| CHEMBL63347 | — | — | 1 | 6.91 |
| CHEMBL66730 | — | — | 1 | 6.08 |
| CHEMBL303435 | — | — | 1 | 5.73 |
| CHEMBL65768 | — | — | 1 | 5.69 |
| CHEMBL63390 | — | — | 1 | 5.54 |
| CHEMBL292738 | — | — | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL304902 | CLOTHIAPINE | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL415300 | ISOCLOZAPINE | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL42 | CLOZAPINE | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL63756 | FLUPERLAPINE | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL67284 | ISOCLOTHIAPINE | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL63576 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 23.4 | nM | 7.63 |
| CHEMBL67298 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL304493 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL63329 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL63590 | — | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL67355 | — | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL303173 | — | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL63347 | — | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL66730 | — | Ki | = | 837.0 | nM | 6.08 |
| CHEMBL303435 | — | Ki | = | 1870.0 | nM | 5.73 |
| CHEMBL65768 | — | Ki | = | 2053.0 | nM | 5.69 |
| CHEMBL63390 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL292738 | — | Ki | = | 7120.0 | nM | 5.15 |