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Assay Detail

CHEMBL617189

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Binding
In vivo binding affinity was evaluated against 5-hydroxytryptamine 2 receptor
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 2A (CHEMBL3446)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Isoindolinone enantiomers having affinity for the dopamine D4 receptor.
Belliotti TR, Brink WA, Kesten SR, Rubin JR, Wustrow DJ, Zoski KT, Whetzel SZ, Corbin AE, Pugsley TA, Heffner TG, Wise LD.
Bioorg Med Chem Lett (1998) 8 : 1499 -1502
PubMed 9873377 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 7.64 7.84

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL37170 1 7.84
CHEMBL35093 1 7.44

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL37170 Ki = 14.6 nM 7.84
CHEMBL35093 Ki = 36.4 nM 7.44