Assay Detail
Binding
CHEMBL617240
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to inhibit binding of [3H]KET to 5-hydroxytryptamine 2 receptor in rat cortex
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Octoclothepin enantiomers. A reinvestigation of their biochemical and pharmacological activity in relation to a new receptor-interaction model for dopamine D-2 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.29 | 9.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL303313 | — | — | 1 | 9.32 |
| CHEMBL64875 | — | — | 1 | 9.32 |
| CHEMBL64249 | CLOROTEPINE | 2.0 | 1 | 9.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL303313 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL64875 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL64249 | CLOROTEPINE | IC50 | = | 0.57 | nM | 9.24 |