Assay Detail
Binding
CHEMBL617242
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity for 5-hydroxytryptamine 2 receptor binding sites by its ability to displace [3H]spiperone from rat frontal cortex.
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
3-[[(Aryloxy)alkyl]piperidinyl]-1,2-benzisoxazoles as D2/5-HT2 antagonists with potential atypical antipsychotic activity: antipsychotic profile of iloperidone (HP 873).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 51 | 7.70 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL276799 | — | — | 1 | 9.15 |
| CHEMBL273307 | — | — | 1 | 9.05 |
| CHEMBL14610 | — | — | 1 | 8.70 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.59 |
| CHEMBL14380 | — | — | 1 | 8.54 |
| CHEMBL14148 | — | — | 1 | 8.49 |
| CHEMBL279996 | — | — | 1 | 8.46 |
| CHEMBL436141 | — | — | 1 | 8.42 |
| CHEMBL14470 | — | — | 1 | 8.42 |
| CHEMBL273907 | — | — | 1 | 8.31 |
| CHEMBL14539 | — | — | 1 | 8.28 |
| CHEMBL14415 | — | — | 1 | 8.28 |
| CHEMBL14322 | — | — | 1 | 8.26 |
| CHEMBL274039 | — | — | 1 | 8.07 |
| CHEMBL14376 | ILOPERIDONE | 4.0 | 1 | 8.05 |
| CHEMBL14163 | — | — | 1 | 7.96 |
| CHEMBL14510 | — | — | 1 | 7.80 |
| CHEMBL14077 | — | — | 1 | 7.80 |
| CHEMBL14100 | — | — | 1 | 7.77 |
| CHEMBL14727 | — | — | 1 | 7.75 |
| CHEMBL14393 | — | — | 1 | 7.70 |
| CHEMBL14681 | — | — | 1 | 7.70 |
| CHEMBL275016 | — | — | 1 | 7.70 |
| CHEMBL14394 | — | — | 1 | 7.66 |
| CHEMBL14365 | — | — | 1 | 7.64 |
| CHEMBL274462 | — | — | 1 | 7.58 |
| CHEMBL427822 | — | — | 1 | 7.48 |
| CHEMBL274223 | — | — | 1 | 7.47 |
| CHEMBL417620 | — | — | 1 | 7.44 |
| CHEMBL14389 | — | — | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL276799 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL273307 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL14610 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL85 | RISPERIDONE | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL14380 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL14148 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL279996 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL436141 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL14470 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL273907 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL14539 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL14415 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL14322 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL274039 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL14376 | ILOPERIDONE | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL14163 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL14510 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL14077 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL14100 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL14727 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL14393 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL14681 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL275016 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL14394 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL14365 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL274462 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL427822 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL274223 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL417620 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL14389 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL14538 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL273633 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL14306 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL14509 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL14361 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL14246 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL14219 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL14158 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL276750 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL14556 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL14348 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL14043 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL14522 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL14206 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL14494 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL54 | HALOPERIDOL | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL275064 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL14218 | — | IC50 | = | 241.0 | nM | 6.62 |
| CHEMBL14395 | — | IC50 | < | 10.0 | nM | - |