Assay Detail
Binding
CHEMBL617249
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Binding affinity towards 5-hydroxytryptamine 2 receptor in rat brain membrane using [3H]8-OH-DPAT as a selective ligand.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Graphics computer-aided receptor mapping as a predictive tool for drug design: development of potent, selective, and stereospecific ligands for the 5-HT1A receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.34 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12311 | — | — | 1 | 6.80 |
| CHEMBL12129 | — | — | 1 | 6.70 |
| CHEMBL12152 | — | — | 1 | 6.20 |
| CHEMBL12124 | — | — | 1 | 6.10 |
| CHEMBL11787 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12311 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL12129 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL12152 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL12124 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL11787 | — | IC50 | = | 1258.93 | nM | 5.90 |