Assay Detail
Binding
CHEMBL617251
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Binding affinity towards 5-hydroxytryptamine 2 receptor in rat frontal cortex using [3H]ketanserin as radioligand
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Frontal cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Graphics computer-aided receptor mapping as a predictive tool for drug design: development of potent, selective, and stereospecific ligands for the 5-HT1A receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.76 | 8.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 8.67 |
| CHEMBL273490 | — | — | 1 | 8.25 |
| CHEMBL275742 | DEXPROPRANOLOL | 2.0 | 1 | 5.10 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267930 | SPIPERONE | IC50 | = | 2.138 | nM | 8.67 |
| CHEMBL273490 | — | IC50 | = | 5.623 | nM | 8.25 |
| CHEMBL275742 | DEXPROPRANOLOL | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL56 | 8-OH-DPAT | IC50 | = | 10000.0 | nM | 5.00 |