Assay Detail
Binding
CHEMBL617252
Review assay metadata, readout intent, target linkage, and publication context from the same page.
isplacement of [3H]DOB from rat cortex homogenate 5-hydroxytryptamine 2 receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Synthesis and serotonergic activity of 5-(oxadiazolyl)tryptamines: potent agonists for 5-HT1D receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.15 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL37462 | — | — | 1 | 6.90 |
| CHEMBL290587 | — | — | 1 | 6.70 |
| CHEMBL39636 | — | — | 1 | 6.60 |
| CHEMBL39317 | L-694247 | — | 1 | 6.50 |
| CHEMBL289489 | — | — | 1 | 6.40 |
| CHEMBL39243 | — | — | 1 | 6.40 |
| CHEMBL37317 | — | — | 1 | 6.10 |
| CHEMBL39331 | — | — | 1 | 6.00 |
| CHEMBL288821 | — | — | 1 | 5.90 |
| CHEMBL36497 | — | — | 1 | 5.80 |
| CHEMBL39296 | — | — | 1 | 5.60 |
| CHEMBL38482 | — | — | 1 | 5.60 |
| CHEMBL39712 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL37462 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL290587 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL39636 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL39317 | L-694247 | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL289489 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL39243 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL37317 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL39331 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL288821 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL36497 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL39296 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL38482 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL39712 | — | IC50 | = | 3162.28 | nM | 5.50 |