Assay Detail
Binding
CHEMBL617287
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory constant against cloned human 5-hydroxytryptamine 2C receptor using with [125I]- DOI radioligand
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.17 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL131736 | — | — | 1 | 8.57 |
| CHEMBL133455 | — | — | 1 | 8.47 |
| CHEMBL134519 | — | — | 1 | 8.40 |
| CHEMBL133868 | — | — | 1 | 8.26 |
| CHEMBL27173 | — | — | 1 | 8.20 |
| CHEMBL275854 | — | — | 1 | 8.18 |
| CHEMBL31115 | — | — | 1 | 8.08 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.08 |
| CHEMBL412876 | — | — | 1 | 7.80 |
| CHEMBL135076 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL131736 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL133455 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL134519 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL133868 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL27173 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL275854 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL31115 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL39 | SEROTONIN | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL412876 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL135076 | — | Ki | = | 20.0 | nM | 7.70 |