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Assay Detail

CHEMBL617288

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Binding
Binding affinity towards human 5-hydroxytryptamine 2C receptor.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 2C (CHEMBL225)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Evaluation of isotryptamine derivatives at 5-HT(2) serotonin receptors.
Chang-Fong J, Addo J, Dukat M, Smith C, Mitchell NA, Herrick-Davis K, Teitler M, Glennon RA.
Bioorg Med Chem Lett (2002) 12 : 155 -158
PubMed 11755343 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 17 6.26 8.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL40815 1 8.05
CHEMBL39347 1 7.38
CHEMBL40726 1 7.07
CHEMBL40816 1 6.52
CHEMBL289061 1 6.48
CHEMBL38742 1 6.31
CHEMBL288445 1 6.28
CHEMBL290779 1 6.25
CHEMBL38633 1 6.14
CHEMBL443258 1 5.84
CHEMBL39417 1 5.70
CHEMBL6393 1 5.32
CHEMBL6385 1 5.29
CHEMBL269073 1 5.00
CHEMBL6503 1 -
CHEMBL41806 1 -
CHEMBL42923 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL40815 Ki = 9.0 nM 8.05
CHEMBL39347 Ki = 42.0 nM 7.38
CHEMBL40726 Ki = 85.0 nM 7.07
CHEMBL40816 Ki = 300.0 nM 6.52
CHEMBL289061 Ki = 330.0 nM 6.48
CHEMBL38742 Ki = 490.0 nM 6.31
CHEMBL288445 Ki = 520.0 nM 6.28
CHEMBL290779 Ki = 560.0 nM 6.25
CHEMBL38633 Ki = 720.0 nM 6.14
CHEMBL443258 Ki = 1460.0 nM 5.84
CHEMBL39417 Ki = 1990.0 nM 5.70
CHEMBL6393 Ki = 4780.0 nM 5.32
CHEMBL6385 Ki = 5160.0 nM 5.29
CHEMBL269073 Ki = 9930.0 nM 5.00
CHEMBL6503 Ki > 10000.0 nM -
CHEMBL41806 Ki > 10000.0 nM -
CHEMBL42923 Ki > 10000.0 nM -