Assay Detail
Binding
CHEMBL617345
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Binding affinity towards 5-hydroxytryptamine 2A receptor using [3H]ketanserin
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structural determinants for high 5-HT(2A) receptor affinity of spiro[9,10-dihydroanthracene]-9,3(')-pyrrolidine (SpAMDA).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.27 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL516 | CYPROHEPTADINE | 4.0 | 1 | 8.52 |
| CHEMBL307956 | — | — | 1 | 8.40 |
| CHEMBL47482 | — | — | 1 | 7.70 |
| CHEMBL73307 | — | — | 1 | 7.28 |
| CHEMBL46566 | — | — | 1 | 7.19 |
| CHEMBL11 | IMIPRAMINE | 4.0 | 1 | 7.03 |
| CHEMBL74766 | — | — | 1 | 7.00 |
| CHEMBL72611 | — | — | 1 | 6.96 |
| CHEMBL76281 | — | — | 1 | 5.34 |
| CHEMBL73783 | — | — | 1 | - |
| CHEMBL75207 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL516 | CYPROHEPTADINE | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL307956 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL47482 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL73307 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL46566 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL11 | IMIPRAMINE | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL74766 | — | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL72611 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL76281 | — | Ki | = | 4610.0 | nM | 5.34 |
| CHEMBL73783 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL75207 | — | Ki | > | 10000.0 | nM | - |