Assay Detail
Binding
CHEMBL617352
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Binding affinity towards serotonin 5-hydroxytryptamine 2A receptor
27
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Chemoenzymatic synthesis and binding affinity of novel (R)- and (S)-3-aminomethyl-1-tetralones, potential atypical antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 7.54 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 9.30 |
| CHEMBL421801 | — | — | 3 | 8.83 |
| CHEMBL155486 | — | — | 3 | 8.57 |
| CHEMBL155388 | — | — | 3 | 8.25 |
| CHEMBL308480 | — | — | 3 | 8.23 |
| CHEMBL155257 | — | — | 3 | 8.14 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.04 |
| CHEMBL153956 | — | — | 3 | 7.95 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 6.78 |
| CHEMBL310153 | — | — | 1 | 6.29 |
| CHEMBL154244 | — | — | 1 | 6.18 |
| CHEMBL348617 | — | — | 1 | 6.16 |
| CHEMBL155426 | — | — | 1 | 6.05 |
| CHEMBL155124 | — | — | 1 | 6.01 |
| CHEMBL157046 | — | — | 1 | 5.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | Ki | = | 0.5012 | nM | 9.30 |
| CHEMBL421801 | — | Ki | = | 1.479 | nM | 8.83 |
| CHEMBL155486 | — | Ki | = | 2.692 | nM | 8.57 |
| CHEMBL155388 | — | Ki | = | 5.623 | nM | 8.25 |
| CHEMBL308480 | — | Ki | = | 5.888 | nM | 8.23 |
| CHEMBL155388 | — | Ki | = | 6.026 | nM | 8.22 |
| CHEMBL155486 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL155257 | — | Ki | = | 7.244 | nM | 8.14 |
| CHEMBL42 | CLOZAPINE | Ki | = | 9.12 | nM | 8.04 |
| CHEMBL155257 | — | Ki | = | 9.55 | nM | 8.02 |
| CHEMBL153956 | — | Ki | = | 11.22 | nM | 7.95 |
| CHEMBL308480 | — | Ki | = | 13.18 | nM | 7.88 |
| CHEMBL153956 | — | Ki | = | 16.22 | nM | 7.79 |
| CHEMBL155257 | — | Ki | = | 16.22 | nM | 7.79 |
| CHEMBL153956 | — | Ki | = | 17.78 | nM | 7.75 |
| CHEMBL308480 | — | Ki | = | 23.44 | nM | 7.63 |
| CHEMBL421801 | — | Ki | = | 26.3 | nM | 7.58 |
| CHEMBL155486 | — | Ki | = | 29.51 | nM | 7.53 |
| CHEMBL155388 | — | Ki | = | 43.65 | nM | 7.36 |
| CHEMBL421801 | — | Ki | = | 45.71 | nM | 7.34 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 165.96 | nM | 6.78 |
| CHEMBL310153 | — | Ki | = | 512.86 | nM | 6.29 |
| CHEMBL154244 | — | Ki | = | 660.69 | nM | 6.18 |
| CHEMBL348617 | — | Ki | = | 691.83 | nM | 6.16 |
| CHEMBL155426 | — | Ki | = | 891.25 | nM | 6.05 |
| CHEMBL155124 | — | Ki | = | 977.24 | nM | 6.01 |
| CHEMBL157046 | — | Ki | = | 2344.23 | nM | 5.63 |