Assay Detail
Binding
CHEMBL617386
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The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 2A receptor from cloned Human membranes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Isochroman-6-carboxamides as highly selective 5-HT1D agonists: potential new treatment for migraine without cardiovascular side effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.76 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71724 | — | — | 1 | 7.12 |
| CHEMBL69385 | — | — | 1 | 6.85 |
| CHEMBL71838 | — | — | 1 | 6.78 |
| CHEMBL71635 | — | — | 1 | 6.61 |
| CHEMBL128 | SUMATRIPTAN | 4.0 | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71724 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL69385 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL71838 | — | Ki | = | 168.0 | nM | 6.78 |
| CHEMBL71635 | — | Ki | = | 248.0 | nM | 6.61 |
| CHEMBL128 | SUMATRIPTAN | Ki | = | 376.0 | nM | 6.42 |