Assay Detail
Binding
CHEMBL617413
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to rat cortical membranes at 5-hydroxytryptamine 2 receptor binding site by using [3H]- DOB as a radioligand
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Central serotonin receptors as targets for drug research.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.39 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69700 | — | — | 1 | 9.40 |
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 9.00 |
| CHEMBL51 | KETANSERIN | 3.0 | 1 | 9.00 |
| CHEMBL18786 | CINANSERIN | 2.0 | 1 | 8.40 |
| CHEMBL8165 | 5-METHOXYTRYPTAMINE | — | 1 | 7.85 |
| CHEMBL18772 | QUIPAZINE | 2.0 | 1 | 7.77 |
| CHEMBL6640 | TRYPTAMINE | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69700 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL267930 | SPIPERONE | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL51 | KETANSERIN | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL18786 | CINANSERIN | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL8165 | 5-METHOXYTRYPTAMINE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL18772 | QUIPAZINE | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL6640 | TRYPTAMINE | Ki | = | 50.0 | nM | 7.30 |