Assay Detail
Binding
CHEMBL617416
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards 5-hydroxytryptamine 2 receptor
17
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.40 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.38 |
| CHEMBL1743803 | — | — | 3 | 8.19 |
| CHEMBL1743798 | — | — | 1 | 8.13 |
| CHEMBL415 | CLOMIPRAMINE | 4.0 | 1 | 8.08 |
| CHEMBL62 | SCH-23390 | — | 1 | 7.89 |
| CHEMBL11 | IMIPRAMINE | 4.0 | 1 | 7.64 |
| CHEMBL287620 | — | — | 1 | 7.54 |
| CHEMBL1743811 | — | — | 1 | 7.54 |
| CHEMBL287257 | DICLOFENSINE | 2.0 | 1 | 7.43 |
| CHEMBL1743790 | — | — | 1 | 7.31 |
| CHEMBL34990 | — | — | 3 | 6.85 |
| CHEMBL286849 | — | — | 1 | 6.22 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL1743803 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL1743798 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL415 | CLOMIPRAMINE | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL1743803 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL62 | SCH-23390 | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL11 | IMIPRAMINE | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL1743811 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL287620 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL287257 | DICLOFENSINE | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL1743790 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL34990 | — | Ki | = | 142.0 | nM | 6.85 |
| CHEMBL34990 | — | Ki | = | 208.0 | nM | 6.68 |
| CHEMBL1743803 | — | Ki | = | 406.0 | nM | 6.39 |
| CHEMBL286849 | — | Ki | = | 602.0 | nM | 6.22 |
| CHEMBL34990 | — | Ki | = | 939.0 | nM | 6.03 |
| CHEMBL41 | FLUOXETINE | Ki | > | 1000.0 | nM | - |