Assay Detail

CHEMBL617422

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity towards serotonin 5-hydroxytryptamine 2 receptor of rat determined using 0.5 nM of [3H]ketanserin in binding assay

ChEMBL ↗

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Target

Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗

Open DB target context

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Serotonin 2 (5-HT2) receptor (CHEMBL2093870) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Serotonin 2 (5-HT2) receptor

CHEMBL2093870

Anchored from Assay target.

Protein identity Serotonin 2 (5-HT2) receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	4 — Cell-line / Tissue
Curated By	Autocuration

Target

Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗

Type	PROTEIN FAMILY
Organism	Rattus norvegicus

Publication

Serotonergic properties of spiroxatrine enantiomers.

Nikam SS, Martin AR, Nelson DL.
J Med Chem (1988) 31 : 1965 -1968
PubMed 2902227 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	2	6.51	6.95

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL300555	SPIROXATRINE	2.0	2	6.95

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL300555	SPIROXATRINE	Ki	=	113.0	nM	6.95
CHEMBL300555	SPIROXATRINE	Ki	=	858.0	nM	6.07