Assay Detail
Binding
CHEMBL617425
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity which represents concentration giving half-maximal inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor rat tissue homogenate
6
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Tissue |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
New antipsychotic agents with serotonin and dopamine antagonist properties based on a pyrrolo[2,1-b][1,3]benzothiazepine structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.42 | 8.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL120512 | — | — | 3 | 8.94 |
| CHEMBL333246 | — | — | 1 | 8.11 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.96 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL120512 | — | Ki | = | 1.14 | nM | 8.94 |
| CHEMBL120512 | — | Ki | = | 1.48 | nM | 8.83 |
| CHEMBL120512 | — | Ki | = | 1.72 | nM | 8.76 |
| CHEMBL333246 | — | Ki | = | 7.85 | nM | 8.11 |
| CHEMBL42 | CLOZAPINE | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL715 | OLANZAPINE | Ki | = | 12.0 | nM | 7.92 |