Assay Detail
Binding
CHEMBL617428
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Compound is evaluated for binding affinity towards 5-hydroxytryptamine 2 receptor using [3H]ketanserin in rat brain
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8.1, 2 synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential alpha1-adrenoceptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.44 | 6.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL320068 | — | — | 1 | 6.94 |
| CHEMBL1744044 | — | — | 1 | 6.78 |
| CHEMBL51433 | — | — | 1 | 6.75 |
| CHEMBL302021 | — | — | 1 | 6.43 |
| CHEMBL106737 | — | — | 1 | 6.42 |
| CHEMBL107084 | — | — | 1 | 6.29 |
| CHEMBL106186 | — | — | 1 | 5.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL320068 | — | Ki | = | 114.0 | nM | 6.94 |
| CHEMBL1744044 | — | Ki | = | 168.0 | nM | 6.78 |
| CHEMBL51433 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL302021 | — | Ki | = | 369.0 | nM | 6.43 |
| CHEMBL106737 | — | Ki | = | 377.0 | nM | 6.42 |
| CHEMBL107084 | — | Ki | = | 514.0 | nM | 6.29 |
| CHEMBL106186 | — | Ki | = | 3580.0 | nM | 5.45 |