Assay Detail
Binding
CHEMBL617432
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for its ability to displace 0.25 nM [125I](R)-DOI from binding sites in rat frontal cortex.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Frontal cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
2,3-Dihydrobenzofuran analogues of hallucinogenic phenethylamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.40 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6607 | BROLAMFETAMINE | 2.0 | 1 | 8.59 |
| CHEMBL94982 | — | — | 1 | 8.51 |
| CHEMBL8600 | DOM | — | 1 | 7.73 |
| CHEMBL94706 | — | — | 1 | 6.84 |
| CHEMBL96079 | — | — | 1 | 6.41 |
| CHEMBL8642 | — | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6607 | BROLAMFETAMINE | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL94982 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL8600 | DOM | Ki | = | 18.6 | nM | 7.73 |
| CHEMBL94706 | — | Ki | = | 146.0 | nM | 6.84 |
| CHEMBL96079 | — | Ki | = | 388.0 | nM | 6.41 |
| CHEMBL8642 | — | Ki | = | 465.0 | nM | 6.33 |