Assay Detail
Binding
CHEMBL617434
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for its ability to displace [3H]ketanserin from serotonergic 5-hydroxytryptamine 2 receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
N-(2-pyrrolidinylmethyl)benzoxazine-8-carboxamides exhibiting high affinities for All of D2, 5-HT1 A, and 5-HT2 receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.19 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279729 | — | — | 1 | 7.07 |
| CHEMBL283528 | — | — | 1 | 6.52 |
| CHEMBL22465 | — | — | 1 | 5.66 |
| CHEMBL280879 | — | — | 1 | 5.52 |
| CHEMBL278762 | — | — | 1 | - |
| CHEMBL284027 | — | — | 1 | - |
| CHEMBL22857 | — | — | 1 | - |
| CHEMBL22777 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279729 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL283528 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL22465 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL280879 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL278762 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL284027 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL22857 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL22777 | — | Ki | > | 1000.0 | nM | - |