Assay Detail
Binding
CHEMBL617437
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Binding affinity against 5-hydroxytryptamine 2 receptor in rat striatum using [3H]-RP62203
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
7-Methyl-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2,3-g]azecine: a new heterocyclic system and a new lead compound for dopamine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.19 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | 8.29 |
| CHEMBL441618 | — | — | 1 | 7.70 |
| CHEMBL62529 | — | — | 1 | 6.75 |
| CHEMBL63063 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6437 | MIANSERIN | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL441618 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL62529 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL63063 | — | Ki | = | 960.0 | nM | 6.02 |