Assay Detail
Binding
CHEMBL617442
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Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor of rat cortex
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 4.92 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274866 | — | — | 1 | 6.80 |
| CHEMBL348140 | — | — | 1 | 5.61 |
| CHEMBL9666 | — | — | 1 | 5.46 |
| CHEMBL160344 | — | — | 1 | 5.33 |
| CHEMBL156216 | — | — | 1 | 5.07 |
| CHEMBL156974 | — | — | 1 | 5.07 |
| CHEMBL266250 | — | — | 1 | 4.76 |
| CHEMBL349562 | — | — | 1 | 4.31 |
| CHEMBL160911 | — | — | 1 | 4.25 |
| CHEMBL348139 | — | — | 1 | 4.19 |
| CHEMBL160121 | — | — | 1 | 4.12 |
| CHEMBL158612 | — | — | 1 | 4.03 |
| CHEMBL158884 | — | — | 1 | - |
| CHEMBL160860 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274866 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL348140 | — | Ki | = | 2430.0 | nM | 5.61 |
| CHEMBL9666 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL160344 | — | Ki | = | 4710.0 | nM | 5.33 |
| CHEMBL156216 | — | Ki | = | 8430.0 | nM | 5.07 |
| CHEMBL156974 | — | Ki | = | 8480.0 | nM | 5.07 |
| CHEMBL266250 | — | Ki | = | 17200.0 | nM | 4.76 |
| CHEMBL349562 | — | Ki | = | 49000.0 | nM | 4.31 |
| CHEMBL160911 | — | Ki | = | 55600.0 | nM | 4.25 |
| CHEMBL348139 | — | Ki | = | 64300.0 | nM | 4.19 |
| CHEMBL160121 | — | Ki | = | 76500.0 | nM | 4.12 |
| CHEMBL158612 | — | Ki | = | 93000.0 | nM | 4.03 |
| CHEMBL158884 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL160860 | — | Ki | > | 100000.0 | nM | - |