Assay Detail
Binding
CHEMBL617447
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Binding affinity to 5-hydroxytryptamine 2 receptor in rat frontal cortical membranes by [3H]- KET displacement.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Central serotonin receptors as targets for drug research.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.05 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51 | KETANSERIN | 3.0 | 1 | 9.00 |
| CHEMBL19215 | METERGOLINE | 2.0 | 1 | 9.00 |
| CHEMBL18331 | PIRENPERONE | 2.0 | 1 | 9.00 |
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 8.70 |
| CHEMBL18786 | CINANSERIN | 2.0 | 1 | 8.40 |
| CHEMBL12314 | MESULERGINE | 2.0 | 1 | 8.40 |
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | 8.00 |
| CHEMBL69700 | — | — | 1 | 7.62 |
| CHEMBL274866 | — | — | 1 | 6.80 |
| CHEMBL18772 | QUIPAZINE | 2.0 | 1 | 6.19 |
| CHEMBL8165 | 5-METHOXYTRYPTAMINE | — | 1 | 6.16 |
| CHEMBL18785 | RU-24969 | — | 1 | 6.00 |
| CHEMBL7257 | MEBUFOTENIN | 2.0 | 1 | 5.92 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 5.53 |
| CHEMBL452861 | LEVOPROPRANOLOL | 2.0 | 1 | 5.46 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 5.15 |
| CHEMBL500 | PINDOLOL | 4.0 | 1 | 4.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51 | KETANSERIN | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL19215 | METERGOLINE | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL18331 | PIRENPERONE | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL267930 | SPIPERONE | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL18786 | CINANSERIN | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL12314 | MESULERGINE | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL6437 | MIANSERIN | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL69700 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL274866 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL18772 | QUIPAZINE | Ki | = | 645.0 | nM | 6.19 |
| CHEMBL8165 | 5-METHOXYTRYPTAMINE | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL18785 | RU-24969 | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL7257 | MEBUFOTENIN | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL39 | SEROTONIN | Ki | = | 2950.0 | nM | 5.53 |
| CHEMBL452861 | LEVOPROPRANOLOL | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 7100.0 | nM | 5.15 |
| CHEMBL500 | PINDOLOL | Ki | = | 29500.0 | nM | 4.53 |