Assay Detail
Binding
CHEMBL617512
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Binding affinity against 5-hydroxytryptamine 2C receptor human cloned receptors in HEK 293 cells using [3H]mesulergine as radioligand
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A novel ergot alkaloid as a 5-HT(1A) inhibitor produced by Dicyma sp.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.53 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL263881 | LYSERGIDE | 2.0 | 1 | 8.30 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 7.30 |
| CHEMBL18840 | — | — | 1 | 5.60 |
| CHEMBL146942 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL263881 | LYSERGIDE | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL39 | SEROTONIN | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL18840 | — | Ki | = | 2511.89 | nM | 5.60 |
| CHEMBL146942 | — | Ki | = | 12589.25 | nM | 4.90 |