Assay Detail
Binding
CHEMBL617517
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory constant determined against cloned human 5-hydroxytryptamine 2A receptor using with [125I]- DOI radioligand
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.15 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135076 | — | — | 1 | 8.44 |
| CHEMBL27173 | — | — | 1 | 8.31 |
| CHEMBL25800 | — | — | 1 | 8.09 |
| CHEMBL412876 | — | — | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135076 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL27173 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL25800 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL412876 | — | Ki | = | 17.0 | nM | 7.77 |